GC–MS strategy for a comprehensive assessment of cannabis metabolome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F25%3A43931830" target="_blank" >RIV/60461373:22330/25:43931830 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0026265X25004163?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0026265X25004163?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.microc.2025.113062" target="_blank" >10.1016/j.microc.2025.113062</a>

Result language
angličtina
Original language name
GC–MS strategy for a comprehensive assessment of cannabis metabolome
Original language description
Cannabis is a very complex plant that provides several potential health benefits. However, these benefits strongly depend on the composition of the present compounds. In this study, we tested and critically evaluated two different sample preparation strategies (with/without derivatization employing N-Methyl-N-(trimethylsilyl)trifluoroacetamide, MSTFA, as a silylating agent) followed by gas chromatography coupled to mass spectrometry (GC–MS). Subsequently, we applied these methods to investigate the metabolome of two chemotypes, including five different varieties of Cannabis. The chemometric methods, such as principal component analysis (PCA) and partial least squares discriminative analysis (PLS-DA), were employed to provide the possibility of distinguishing cannabis varieties based on their metabolome. In the next step, significant compounds (‘markers’) for each variety (or varieties) were found and identified. For the identification of ‘markers’, the NIST library, in combination with an ‘in house’ developed database containing high-resolution mass spectra of 26 neutral cannabinoids and 38 MSTFA derivates, was used. © 2025
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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