Stoichiometric network analysis of MAPK cascade

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F10%3A00023260" target="_blank" >RIV/60461373:22340/10:00023260 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Stoichiometric network analysis of MAPK cascade

Original language description

The Mitogen Activated Protein Kinase (MAPK) cascade is a highly conserved series of three protein kinases that conducts information signals to operate diverse biological processes. A parameter model of signal transduction produce nonlinear behaviour likebistability and oscillations. The reaction mechanism of MAPK cascade is composed from twelve biochemical reactions creating a larger chemical network. Methods of stoichiometric network analysis (SNA) are used to separate the entire network into irreducible subnetworks and then apply linear stability analysis to reveal potential dynamical instabilities. Finally, unstable subnetwork that evokes oscillatory behaviour has been identified.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

CI - Industrial chemistry and chemical engineering

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Reakční a transportní jevy IV

ISBN

978-80-7080-761-3

ISSN

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e-ISSN

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Number of pages

6

Pages from-to

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Publisher name

VŠCHT Praha

Place of publication

Praha

Event location

Litomyšl

Event date

Jan 1, 2010

Type of event by nationality

CST - Celostátní akce

UT code for WoS article

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