On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895784" target="_blank" >RIV/60461373:22340/13:43895784 - isvavai.cz</a>
Result on the web
<a href="http://scitation.aip.org/content/aip/journal/jcp/138/6/10.1063/1.4790126" target="_blank" >http://scitation.aip.org/content/aip/journal/jcp/138/6/10.1063/1.4790126</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1063/1.4790126" target="_blank" >10.1063/1.4790126</a>

Result language
angličtina
Original language name
On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling
Original language description
Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. Successive phosphorylation cascades mediated by MAPKs serve as sensitive switches initiating various cellular processes. Apart from this basic feature, the underlying reaction network is capable of displaying other nonlinear phenomena including bistable steady states and hysteresis as well as periodic oscillations. We show that from the mechanistic point of view, bistability is a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in a Stage 2 subsystem of the Huang-Ferrell model. Within this subsystem we uncover the core subnetwork obtained by systematic reduction relying on the methods of stoichiometric network analysis. For the core model we show that there is either one stable steady state or three steady states of which two are stable and point out the role of interplay betwe
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Project
<a href="/en/project/ME10036" target="_blank" >ME10036: Effects of convective transport on chemical signal propagation in living tissues</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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