The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895757" target="_blank" >RIV/60461373:22340/13:43895757 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1134/S0036024413130116" target="_blank" >http://dx.doi.org/10.1134/S0036024413130116</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1134/S0036024413130116" target="_blank" >10.1134/S0036024413130116</a>
Alternative languages
Result language
angličtina
Original language name
The SNA analysis of a minimal model for bistability in the MAPK signaling cascade model
Original language description
Successive phosphorylation cascades mediated by mitogen-activated protein kinases (MAPKs) are known to act as switches initiating various cellular processes. In addition, models of the MAPK reaction network are displaying other nonlinear phenomena including bistability and periodic oscillations. Recently bistability has been explained as a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in the Stage 2 subsystem of the Huang-Ferrell model of the MAPK and acore bistable model has been proposed. Here we focus on a detailed stability analysis of the steady states of this minimal model. The analysis uses methods of convex analysis and stoichiometric network theory.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ME10036" target="_blank" >ME10036: Effects of convective transport on chemical signal propagation in living tissues</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Russian Journal of Physical Chemistry A
ISSN
0036-0244
e-ISSN
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Volume of the periodical
87
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
2160-2165
UT code for WoS article
000324296400022
EID of the result in the Scopus database
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