Stoichiometric network analysis of MAPK signalling cascade
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43894044" target="_blank" >RIV/60461373:22340/12:43894044 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Stoichiometric network analysis of MAPK signalling cascade
Original language description
The Mitogen Activated Protein Kinase (MAPK) cascade, one of most studied signalling systems, is a highly conserved series of three protein kinases that conducts information signals to operate diverse biological processes. This cascade topology has unexpected consequences for dynamics of the MAPK signalling. The Huang-Ferrell model of MAPK signal transduction produce nonlinear behaviour like bistability and oscillations. Using reaction network theory, we analysed the Huang-Ferrell model of MAPK, especially a system involving activation of MAPKKK and first of the two double-phosphorylation cascades. We found the smallest network which still preserves bistability but does not allow for oscillations, and identified the unstable subnetwork that evokes oscillatory behaviour. We analyzed the single-phosphorylation cascade model by using numerical continuation and determine what is the role of various subnetworks in forming the bistability. The SNA was used to find the smallest network which s
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ME10036" target="_blank" >ME10036: Effects of convective transport on chemical signal propagation in living tissues</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
20th International Congress of Chemical and Process Engineering
ISBN
978-80-905035-1-9
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
1-3
Publisher name
Orgit, s.r.o.
Place of publication
Praha
Event location
Prague
Event date
Aug 25, 2012
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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