Complex traveling wave phenomena mediated by the coupling of phosphorylation cascades and extracellular diffusion in cellular populations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43902406" target="_blank" >RIV/60461373:22340/16:43902406 - isvavai.cz</a>

Result on the web

<a href="http://www3.aiche.org/proceedings/Abstract.aspx?ConfID=Annual-2016&GroupID=2160&SessionID=32313&PaperID=462800" target="_blank" >http://www3.aiche.org/proceedings/Abstract.aspx?ConfID=Annual-2016&GroupID=2160&SessionID=32313&PaperID=462800</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Complex traveling wave phenomena mediated by the coupling of phosphorylation cascades and extracellular diffusion in cellular populations

Original language description

Here we will present a possible mechanism that can serve for the propagation of specific MAPK activity in cellular populations. The intracellular MAPK subnetwork is coupled with ligand-receptor signaling processes in our model. Spatially one dimensional extracellular domain that allows for ligand diffusion, ligand release and ligand interaction with membrane receptors is considered. Ligand-receptor complexes formed on the cytosolic membrane represents an input to the MAPK cascade. It is assumed that a double-phosphorylated kinase of MAPK cascade activates a specific protease responsible for the ligand release into extracellular space and thus closes a feedback loop. We will show that this coupling leads to the coexistence of one, two or three different steady states, or to the coexistence of a stable steady state and periodic solution. We systematically study the behavior of two identical cellular populations at the place of their contact. These populations differ only by initial conditions that are expressed as a particular stable steady state or periodic regime. We have found that traveling waves of MAPK activity typically appear at the place of contact. The propagation velocities and character strongly depend on the selected initial states of the two populations. The results of our systematic study and classification of the propagating waves will be presented.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

CI - Industrial chemistry and chemical engineering

OECD FORD branch

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Project

<a href="/en/project/LH14009" target="_blank" >LH14009: Instabilities and dynamics of functional motifs in biochemical networks</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

AIChE 2016 Annual Meeting

ISBN

978-0-8169-1097-7

ISSN

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e-ISSN

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Number of pages

22

Pages from-to

"398h-1"-"398h-22"

Publisher name

American Institute of Chemical Engineers (AIChE)

Place of publication

New York

Event location

San Francisco

Event date

Nov 13, 2016

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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