Traveling-wave Phenomena in a Model of Autocrine Signaling Coupled with Dynamics of the MAPK Cascade
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F18%3A43915899" target="_blank" >RIV/60461373:22340/18:43915899 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/ijch.201700117" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/ijch.201700117</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijch.201700117" target="_blank" >10.1002/ijch.201700117</a>
Alternative languages
Result language
angličtina
Original language name
Traveling-wave Phenomena in a Model of Autocrine Signaling Coupled with Dynamics of the MAPK Cascade
Original language description
Recently we have revealed a minimal reaction subnetwork in the MAPK (mitogen-activated protein kinase) cascade that is responsible for the emergence of bistable and oscillatory behavior. Here we examine a possible mechanism that provides for the propagation of increased MAPK activity in cell populations by interconnecting the intracellular MAPK subnetwork with the ligand-receptor signaling machinery. Such approach allows for significant reduction of the dimensionality of the parameter space on one hand and the conservation of dynamical complexity of the system on the other hand. The coupled model predicts coexistence of one, two or three different stable steady states, or the coexistence of a stable steady state and periodic solution. We found two robust and physiologically relevant characteristics of the proposed model: (i) There is a very large region of coexistence of at least one stable steady state with non-zero MAPK activity and one steady state with zero MAPK activity in the parameter space. (ii) Spontaneous traveling front waves always switching originally inactive cells into ligand releasing cells emerge in adjacent cell populations, e.g. in healthy and injured tissues. Moreover, the formation of composite traveling front waves and spatial oscillatory patterns of MAPK activity are predicted and discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
<a href="/en/project/LH14009" target="_blank" >LH14009: Instabilities and dynamics of functional motifs in biochemical networks</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Israel Journal of Chemistry
ISSN
0021-2148
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
6-7
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
742-752
UT code for WoS article
000439931200009
EID of the result in the Scopus database
2-s2.0-85037648937