Dynamics and transfer of excitation in heart tissue

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F10%3A00023319" target="_blank" >RIV/60461373:22340/10:00023319 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Dynamics and transfer of excitation in heart tissue
Original language description
The cardiac tissue was selected for the purpose of the study of the dynamics and the transfer of excitations. The heart cells are excitable. Their cytoplasmic membranes respond to the depolarization by opening calcium channels and then calcium ions enterthe cells. In reaction to the elevated cytosolic calcium levels the ryanodine receptors in sarcoplasmic reticulum (SR) membrane open. This causes an efflux of calcium ions from the SR into the cytoplasm and raises the Ca levels even more. This mechanismis called Calcium-Induced Calcium Release, commonly abbreviated as CICR. The transfer of excitations between myocytes is provided by the presence of gap junctions--intercellular connections forming aqueous pores. Thus the transfer of Ca ions between cells is possible. The model of myocyte was adopted from the literature and studied using methods of analysis of nonlinear dynamical systems. The cell response to a step change of cytoplasmic membrane voltage was studied. Using a
Czech name
—
Czech description
—

Project
<a href="/en/project/GA203%2F09%2F2091" target="_blank" >GA203/09/2091: Functional dynamics of heterogeneous-chemical and biochemical reaction systems with the use of reaction network analysis</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)