Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F11%3A43892159" target="_blank" >RIV/60461373:22340/11:43892159 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.compchemeng.2010.07.008" target="_blank" >http://dx.doi.org/10.1016/j.compchemeng.2010.07.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.compchemeng.2010.07.008" target="_blank" >10.1016/j.compchemeng.2010.07.008</a>
Alternative languages
Result language
angličtina
Original language name
Microstructure based mathematical modelling and spectroscopic imaging of tablet dissolution
Original language description
A computer model was developed with the objective of modelling pharmaceutical tablet dissolution with non-swelling excipients. The model, which allows the explicit description of the tablets heterogeneous microstructure, was verified using Fourier Transform Infrared (FTIR) spectroscopic imaging and UV-visible spectroscopy. Two parametric studies were conducted using the model for binary tablets. One investigated the effect of particle size and tablet composition on component release times and the otherstudied the effect of changing the diffusivity and solubility of one component on the release times of both. Tablets containing Polyethylene Glycol (PEG) 4000 and nicotinamide were used in the experiments. Physical properties of pure components were obtained from literature and also experiments using tablets containing 100% and 10% (w/w) nicotinamide. The model was then used to predict the dissolution of a tablet containing 40% (w/w) nicotinamide which matched the experiment with a mean
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
—
Result continuities
Project
—
Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
COMPUTERS & CHEMICAL ENGINEERING
ISSN
0098-1354
e-ISSN
—
Volume of the periodical
35
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
1328-1339
UT code for WoS article
000292093700015
EID of the result in the Scopus database
—