Formulation design space analysis for drug release from swelling polymer tablets

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895522" target="_blank" >RIV/60461373:22340/13:43895522 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.powtec.2012.02.027" target="_blank" >http://dx.doi.org/10.1016/j.powtec.2012.02.027</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2012.02.027" target="_blank" >10.1016/j.powtec.2012.02.027</a>

Result language

angličtina

Original language name

Formulation design space analysis for drug release from swelling polymer tablets

Original language description

A model is presented which can be used to simulate polymer swelling and drug release from tablets using a combination of the Discrete Element Method (DEM) and solving mass transfer over an unstructured grid formed by the DEM elements. This work extends arecently developed single-component swelling and dissolution model by incorporating an extra component (drug) that can be either homogeneously or heterogeneously dispersed within the tablet. Parametric studies were conducted on some of the key parameters which affect drug release, namely the drug distribution, maximum swelling ratio of the polymer and the drug-polymer diffusivity dependence. The drug heterogeneity study showed that burst release (i.e. dose-dumping) increased as drug loading increased since the polymer could not form a gel layer to surround the tablet but the time taken for 99% drug release was not significantly different when compared to the homogeneous case. The maximum swelling ratio study showed that drug release co

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CI - Industrial chemistry and chemical engineering

OECD FORD branch

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Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Powder Technology

ISSN

0032-5910

e-ISSN

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Volume of the periodical

236

Issue of the periodical within the volume

February 2013

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

179-187

UT code for WoS article

000316516300022

EID of the result in the Scopus database

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