DEM simulation of drug release from structurally heterogeneous swelling tablets
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895513" target="_blank" >RIV/60461373:22340/13:43895513 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.powtec.2012.12.039" target="_blank" >http://dx.doi.org/10.1016/j.powtec.2012.12.039</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.powtec.2012.12.039" target="_blank" >10.1016/j.powtec.2012.12.039</a>
Alternative languages
Result language
angličtina
Original language name
DEM simulation of drug release from structurally heterogeneous swelling tablets
Original language description
The Discrete Element Method (DEM) was used to generate an unstructured mesh over which mass transfer equations were solved. This has been applied to model swelling and drug release from pharmaceutical tablets and is useful for studying in vitro?in vivo correlation (IVIVC) and virtual formulation development. Parametric studies were conducted into the effect of tablet shape and aspect ratio, polymer properties and shell thickness, and boundary conditions around the tablet on drug release time (t90), theshape of the release curve and tablet evolution. The first study showed that drug release from tablets containing the same mass of polymer and drug but having different shapes and aspect ratios was only dependent on aspect ratio and not tablet shape. Investigations into polymer properties and coating thickness showed that drug release is fastest for moderately swelling polymers and that similar t90 can be obtained for different combinations of parameters. The final study into different b
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
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Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Powder Technology
ISSN
0032-5910
e-ISSN
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Volume of the periodical
248
Issue of the periodical within the volume
November 2013
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
68-76
UT code for WoS article
000325843400007
EID of the result in the Scopus database
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