Effects of convective flow and extracellular inhibitors on EGFR signaling - mathematical modeling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F11%3A43892280" target="_blank" >RIV/60461373:22340/11:43892280 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effects of convective flow and extracellular inhibitors on EGFR signaling - mathematical modeling
Original language description
We study effects of convective flow on velocity of signal transmission in epithelial tissue. It has been found that the convective transport is necessary in many developmental processes such as vascular and lymphatic system formation. Here, we focus on aone-layer epithelium system. We consider positive feedback loop ligand transport -} ligand-receptor binding -} intracellular processing -} ligand release. When a combination of diffusion and convective transport is considered in the extracellular space,we can see different regimes of ligand propagation or withdrawal at the epithelium. Parametrical studies dealing with effects of strength of ligand-receptor binding, geometric parameters, importance of ligand-receptor endocytosis or relative strength ofligand formation on signal propagation will be shown. We have developed three mathematical models that differ according to flow character above the epithelium: (i) plug flow along the epithelium, (ii) simplified plug flow model that expl
Czech name
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Czech description
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Project
<a href="/en/project/ME10036" target="_blank" >ME10036: Effects of convective transport on chemical signal propagation in living tissues</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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