Effects of Convective Transport on Chemical Signal Propagation in Epithelia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893537" target="_blank" >RIV/60461373:22340/12:43893537 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0006349512001531" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0006349512001531</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bpj.2012.01.038" target="_blank" >10.1016/j.bpj.2012.01.038</a>

Result language

angličtina

Original language name

Effects of Convective Transport on Chemical Signal Propagation in Epithelia

Original language description

We study effects of convective transport on a chemical front wave representing a signal propagation at a simple (single layer) epithelium by means of mathematical modeling. Plug flow and laminar flow regimes were considered. We observed a nonmonotonous dependence of the propagation velocity on the ligand receptor binding constant under influence of the convective transport. If the signal propagates downstream, the region of high velocities becomes much broader and spreads over several orders of magnitude of the binding constant. When the convective transport is oriented against the propagating signal, either velocity of the traveling front wave is slowed down or the traveling front wave can stop or reverse the direction of propagation. More importantly, chemical signal in epithelial systems influenced by the convective transport can propagate almost independently of the ligand-receptor binding constant in a broad range of this parameter.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOPHYSICAL JOURNAL

ISSN

0006-3495

e-ISSN

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Volume of the periodical

102

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

990-1000

UT code for WoS article

000301280900005

EID of the result in the Scopus database

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