Computational and experimental investigation of needle-shaped crystal breakage

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F11%3A43892337" target="_blank" >RIV/60461373:22340/11:43892337 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.ijpharm.2010.12.031" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2010.12.031</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2010.12.031" target="_blank" >10.1016/j.ijpharm.2010.12.031</a>

Result language

angličtina

Original language name

Computational and experimental investigation of needle-shaped crystal breakage

Original language description

Needle-shaped crystals are a common occurrence in many pharmaceutical and fine chemicals processes. Even if the particle size distribution (PSD) obtained in a crystallization step can be controlled by the crystal growth kinetics and hydrodynamic conditions, further fluid-solid separation steps such as filtration, filter washing, drying, and subsequent solids handling can often lead to uncontrolled changes in the PSD due to breakage. In this contribution we present a combined computational and experimental methodology for determining the breakage kernel and the daughter distribution functions of needle-shaped crystals, and for population balance modeling of their breakage. A discrete element model (DEM) of needle-shaped particle breakage was first usedin order to find out the appropriate types of the breakage kernel and the daughter distribution functions. A population balance model of breakage was then formulated and used in conjunction with experimental data in order to determine the

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CI - Industrial chemistry and chemical engineering

OECD FORD branch

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Project

<a href="/en/project/GP104%2F08%2FP389" target="_blank" >GP104/08/P389: Mesoscopic modeling of complex materials formation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal Pharm.

ISSN

0378-5173

e-ISSN

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Volume of the periodical

407

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

12-20

UT code for WoS article

000288777400002

EID of the result in the Scopus database

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