Transport properties of silica-coated alginate microparticles for controlled delivery

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893597" target="_blank" >RIV/60461373:22340/12:43893597 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Transport properties of silica-coated alginate microparticles for controlled delivery
Original language description
The aim of this work is to produce silica-coated alginate microparticles with specific controllable shell structure for applications in drug and other chemicals delivery. The microparticles were synthesis in two steps [1, 2]. In the first step, alginategel core were prepared by the drop-on-demand inkjet technology and in the second step the organo-silica shell has been formed by a sol-gel process using alkoxysilane precursors. Using this method, after hydrolysis and polycondensation of precursors, a thin (~1 mým) silica shell precipitates on the alginate cores. Furthermore, pre-synthesised silica nanoparticles can be incorporated into the newly formed silica shell. The specific objective of this work is to systematically investigate the transport properties of this layer by measuring the diffusion rates of a range of proteins with increasing molar weight (14 kDa - 66 kDa). Knowledge of the diffusion rate across the silica shell as function of the protein size is a key for the future a
Czech name
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Czech description
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
39th International Conference of Slovak Society of Chemical Engineering
ISBN
978-80-89475-04-9
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
1031-1035
Publisher name
Slovak Society of Chemical Engineering
Place of publication
Bratislava
Event location
Tatranské Matliare
Event date
May 21, 2012
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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