Characterization of temperature dependent release rate from liposomes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893600" target="_blank" >RIV/60461373:22340/12:43893600 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Characterization of temperature dependent release rate from liposomes
Original language description
Liposomes are nanoscaled vesicles. They are able to encapsulate various types of substances because of phospoholipid bilayer that forms their shell. The membrane undergoes phase change at certain temperature that makes bilayer much more permeable than atlower temperatures. This phenomenon can be used for example in medicine for delivery of drugs. Liposomes can be imagined as small reservoir that can contain reactants that will be released from the vesicles after heating. Liposomes were prepared by hydration method using sonication, resp. extrusion as a homogenizing process. The vesicles have diameter of 50 nm to 200 nm depending on preparation conditions. 5(6)-carboxyfluorescein (CF) was chosen as a model substance. Amount of leaked CF was determinedby fluorescence spectroscopy. This work will show release rate studies of liposomes with different composition of their membranes meaning different temperatures of phase-change. The liposomes were made from dipalmitoylphosphatidylcholine
Czech name
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Czech description
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
39th International Conference of Slovak Society of Chemical Engineering
ISBN
978-80-89475-04-9
ISSN
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e-ISSN
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Number of pages
7
Pages from-to
1209-1215
Publisher name
Slovak Society of Chemical Engineering
Place of publication
Bratislava
Event location
Tatranské Matliare
Event date
May 21, 2012
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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