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Investigation of temperature-dependent release kinetics from free and immobilized liposomes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893623" target="_blank" >RIV/60461373:22340/12:43893623 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Investigation of temperature-dependent release kinetics from free and immobilized liposomes

  • Original language description

    The early liposome-based medicaments employed the idea of slow release and hence the medicinal effect is prolonged. However, the liposomes have more potential. Depending on its composition, the phospholipid bilayer undergoes a phase transition that makesthe membrane much more permeable. The membrane is solid-like and little permeable at lower temperatures. At a phase transition temperature, the bilayer melts to liquid-like structure characterized by more mobile phospholipid molecules, which causes themembrane to be more permeable and less rigid. The phase change temperature is characteristic to the phospholipid bilayer; it depends on a length and a saturation of fatty acids chains and it is different for a particular polar head type. An existence ofthe phase change makes the release from liposomes controllable by temperature.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CI - Industrial chemistry and chemical engineering

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    CHOBOTIX 2012

  • ISBN

    978-80-7080-813-9

  • ISSN

  • e-ISSN

  • Number of pages

    7

  • Pages from-to

    8-14

  • Publisher name

    ICT Press, VŠCHT Praha

  • Place of publication

    Praha

  • Event location

    Praha

  • Event date

    May 10, 2012

  • Type of event by nationality

    CST - Celostátní akce

  • UT code for WoS article