Investigation of temperature-dependent release kinetics from free and immobilized liposomes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893623" target="_blank" >RIV/60461373:22340/12:43893623 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Investigation of temperature-dependent release kinetics from free and immobilized liposomes
Original language description
The early liposome-based medicaments employed the idea of slow release and hence the medicinal effect is prolonged. However, the liposomes have more potential. Depending on its composition, the phospholipid bilayer undergoes a phase transition that makesthe membrane much more permeable. The membrane is solid-like and little permeable at lower temperatures. At a phase transition temperature, the bilayer melts to liquid-like structure characterized by more mobile phospholipid molecules, which causes themembrane to be more permeable and less rigid. The phase change temperature is characteristic to the phospholipid bilayer; it depends on a length and a saturation of fatty acids chains and it is different for a particular polar head type. An existence ofthe phase change makes the release from liposomes controllable by temperature.
Czech name
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Czech description
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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