Feasibility and constraints of particle targeting using the antigen-antibody interaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895405" target="_blank" >RIV/60461373:22340/13:43895405 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/13:00423266
Result on the web
<a href="http://dx.doi.org/10.1039/C3NR04340A" target="_blank" >http://dx.doi.org/10.1039/C3NR04340A</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C3NR04340A" target="_blank" >10.1039/C3NR04340A</a>
Alternative languages
Result language
angličtina
Original language name
Feasibility and constraints of particle targeting using the antigen-antibody interaction
Original language description
This work is concerned with the surface modification of fluorescent silica nanoparticles by a monoclonal antibody (M75) and the specific bioadhesion of such particles to surfaces containing the PG domain of carbonic anhydrase IX (CA IX), which is a trans-membrane protein specifically expressed on the surfaces of several tumor cell lines. The adhesion strength of antibody-bearing silica nanoparticles to antigen-bearing surfaces was investigated under laminar flow conditions in a microfluidic cell and compared to the adhesion of unmodified silica nanoparticles and nanoparticles coupled with an unspecific antibody. Adhesion to cancer cells using flow cytometry was also investigated and in all cases the adhesion strength of M75-modified nanoparticles was significantly stronger than for the unmodified or unspecific nanoparticles, up to several orders of magnitude in some cases. The specific modification of nano- and microparticles by an antibody-like protein therefore appears to be a feasib
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA13-37055S" target="_blank" >GA13-37055S: Remote Control of Adhesion and Reaction-Diffusion Process in Structured Microparticles</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscale
ISSN
2040-3364
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
03 Oct 2013
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
11490-11498
UT code for WoS article
000326982000016
EID of the result in the Scopus database
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