EFFECT OF HYDROPHOBIC INCLUSIONS ON POLYMER SWELLING KINETICS STUDIED BY MAGNETIC RESONANCE IMAGING
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43900357" target="_blank" >RIV/60461373:22340/15:43900357 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
EFFECT OF HYDROPHOBIC INCLUSIONS ON POLYMER SWELLING KINETICS STUDIED BY MAGNETIC RESONANCE IMAGING
Original language description
Controlled delivery systems are widely used formulations in the pharmaceutical industry. Binding the active pharmaceutical ingredient (API) into the drug delivery system can solve some disadvantages of regular oral dosage forms. The simplest controlled delivery systems are polymeric matrices mixed with the API and excipients, further directly compressed into the tablet. Hydrophilic polymeric matrices create a gel layer after contact with a dissolution medium. This gel layer represents the regulation mechanism of the API liberation (by influencing the water penetration into the solid core of the tablet, its diffusion through the gel layer, the drug particle dissolution and the diffusion through the gel layer or the polymer chain disentanglement). Despite the remarkable accomplishments in this field of study, there are still a lot of unknowns in the design of swellable drug delivery systems. It is complicated to produce the final formulation with desired dissolution profile of the API. I
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA13-09914S" target="_blank" >GA13-09914S: A controlling of diffusion processes in pores with varying permeability</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the 3rd International Conference on Chemical Technology
ISBN
978-80-86238-79-1
ISSN
2336-811X
e-ISSN
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Number of pages
5
Pages from-to
489-493
Publisher name
Česká společnost průmyslové chemie (ČSPCH)
Place of publication
Praha
Event location
Mikulov
Event date
Apr 13, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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