Quantifying the effect of fillers on the breakage behaviour of needle-shaped particles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43901969" target="_blank" >RIV/60461373:22340/16:43901969 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.apt.2016.03.018" target="_blank" >http://dx.doi.org/10.1016/j.apt.2016.03.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.apt.2016.03.018" target="_blank" >10.1016/j.apt.2016.03.018</a>

Result language
angličtina
Original language name
Quantifying the effect of fillers on the breakage behaviour of needle-shaped particles
Original language description
Understanding the relationship between the applied stress and the behaviour of packings of breakable granular particles is required in many chemical engineering applications. A pharmaceutical tablet is an example where a composite packing (a packing containing a mixture of several kinds of particles) is compacted in the process of tablet formation. In this work, the unidirectional compaction and the breakage processes in composite packings formed from a mixture of breakable needle-shaped crystals and elastic spherical filler particles were studied using a Discrete Element Method (DEM) simulation. The evolution of crystal size distribution and contacts topology with the increasing stress was computed for different relative size, volume fraction and elasticity of filler particles inside the packing. We show that crystals breakability in a packing is directly related to the number of contacts among particles and that it can be significantly influenced by an appropriate choice of added filler particles. The results can be used for the development of mathematical models that describe the pharmaceutical tablet production and other processes involving composite packings of fragile particles.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Project
<a href="/en/project/GA15-05534S" target="_blank" >GA15-05534S: Structure-property relationships and breakage dynamics of complex granular material</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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