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Formation of 3D multicellular spheroids in liquid marble

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43902161" target="_blank" >RIV/60461373:22340/16:43902161 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Formation of 3D multicellular spheroids in liquid marble

  • Original language description

    We successfully proved the creation of spheroids by human colorectal adenocarcinoma cell line (HT-29) by usage of the liquid marbles, liquid droplets encapsulated by hydrophobic powder. During the cultivation cells spontaneously formed the spherical agglomerates (spheroids) without the scaffold. The study focused on the influence of different parameters (volume, cell density, day) on final harvest. To evaluate the harvest we counted the number of created spheroids and the total number of cells. Better simulation of living body is essential to increase the efficiency of drug development. In vivo conditions are significantly different comparing to in vitro conditions. Today used cell monolayers (2D structures of cells) are not accurate enough to simulate living organism, but growing cells as 3D structure have more potential. Drug absorption, distribution, metabolism, excretion and toxicity could be tested on these 3D multicellular spheroids, decrease the use of animal models and accelerate the drug development.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CI - Industrial chemistry and chemical engineering

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA13-37055S" target="_blank" >GA13-37055S: Remote Control of Adhesion and Reaction-Diffusion Process in Structured Microparticles</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    Proceedings 43rd International Conference of the Slovak Society of Chemical Engineering

  • ISBN

    978-80-89597-35-2

  • ISSN

  • e-ISSN

  • Number of pages

    8

  • Pages from-to

    283-290

  • Publisher name

    Slovak Society of Chemical Engineering

  • Place of publication

    Bratislava

  • Event location

    Tatranské Matliare

  • Event date

    May 23, 2016

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article