Molecular-spectroscopic analysis of blood plasma of patients with pancreatic cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43903273" target="_blank" >RIV/60461373:22340/16:43903273 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Molecular-spectroscopic analysis of blood plasma of patients with pancreatic cancer

Original language description

Pancreatic cancer (PC) is one of the most aggressive cancer types; and thus, it represents the most common cause of cancer death. The absence of highly specific biomarkers and the low reliability of current diagnostic procedures do not facilitate a proper early-stage diagnosis. Moreover, the disease is often misdiagnosed, because some of the early-stage symptoms appear similar to those of type II diabetes mellitus (DM2). With the onset of cancer, the changes in content and conformation of several biomolecules, including peptides and proteins, may be observed in blood plasma. Hence, we performed the spectroscopic analysis of blood plasma of patients with PC, DM2 and healthy subjects using chiroptical methods. Raman optical activity (ROA) and electronic circular dichroism (ECD), both of which are inherently sensitive to 3D structure of chiral molecules, were supplemented by non-polarized vibrational techniques, specifically Raman and infrared spectroscopy. We were able to distinguish not only healthy from diseased subjects with high level of accuracy, but we have also identified the variations of the spectral response between PC and DM2. According to the achieved results, the combination of chiroptical and vibrational spectroscopies might have a promising potential for the identification of subjects in the early-stage of PC.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/NV16-31028A" target="_blank" >NV16-31028A: Efficacy of new spectroscopic biomarkers for detection of early stage pancreatic cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů