Application of matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with LC-MS in pharmacokinetic study of metformin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F18%3A43913595" target="_blank" >RIV/60461373:22340/18:43913595 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/18:00489365
Result on the web
<a href="https://www.future-science.com/doi/full/10.4155/bio-2017-0190" target="_blank" >https://www.future-science.com/doi/full/10.4155/bio-2017-0190</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4155/bio-2017-0190" target="_blank" >10.4155/bio-2017-0190</a>
Alternative languages
Result language
angličtina
Original language name
Application of matrix-assisted laser desorption/ionization mass spectrometry imaging in combination with LC-MS in pharmacokinetic study of metformin
Original language description
To demonstrate and discuss the pros and cons of various conventional and innovative analytical approaches. Methodology & results: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MSI) of tissue sections as well as the extraction of tissue homogenates, blood plasma and dried blood spots coupled with LC-MS were employed to monitor the pharmacokinetics of metformin in mice. The time profile of metformin measured by matrix-assisted laser desorption/ionization MSI correlated well with the results found by LC-MS. Repeatability of the preparation of tissue sections for MSI was very good. Conclusion: MSI provided valuable information on the spatial distribution and relative concentration of the analyte within tissue sections. The analysis of the extracts of tissue homogenates, blood plasma and blood spots provided quantitative data on metformin. The dried blood spot approach is a progressive method of sampling, especially in studies where the amount of available blood is limited.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/LO1601" target="_blank" >LO1601: Prague University Analytical Centre II and III - NPU 2015-2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioanalysis
ISSN
1757-6180
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
71-81
UT code for WoS article
000419158500003
EID of the result in the Scopus database
2-s2.0-85040198311