THE GLUCAN PARTICLES AS POTENTIAL CARRIERS FOR ANTI-INFLAMMATORY DRUGS

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43919865" target="_blank" >RIV/60461373:22340/19:43919865 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/19:43919873

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

THE GLUCAN PARTICLES AS POTENTIAL CARRIERS FOR ANTI-INFLAMMATORY DRUGS

Original language description

Introduction: One of the novel methods of pharmaceutical formulation is the loading of the drug into biocompatible microparticles, preferably extracted from natural sources. This approach offers several potential advantages compared to conventional drug delivery methods, enabling the option of oral administration even for wider group of drugs. Multiple principles of the loading process are possible – adsorption onto the particle surface or precipitation inside the pores of a hollow particle. The presented work focuses on precipitation of a drug from an organic solvent inside microparticles - glucan particles. Glucan particles (GPs) are ellipsoid porous shells, which are obtained from cells of Saccharomyces cerevisiae (baker’s yeast). The particle size is 2-5 micrometers. Cell walls of glucan particles are mainly composed of β-1,3-glucans. GPs can be used as a vehicle, since β-1,3-glucan can interact with immune system in organism, especially with lymphatic cells. Lymphatic cells are mainly present in inflammation areas in organism where they play an important role in the process of inflammation. GPs interact with lymphatic cell’s receptors on their surface and after that GPs are phagocytosed by the lymphatic cells. Prepared GPs can be loaded with various active compounds, including natural substances and then deliver their content into the target area - in this case in the inflamed area. Therefore, GPs can represent an effective delivery system of biological active substances. The other advantage of GPs is that they can be deliver to organism per os. In this project curcumin was tested due to its anti-inflammatory activity. Curcumin is an antioxidant and anti-inflammatory flavonoid, which occurs in plants of family Zingiberacaea. Loading of curcumin into GPs was enabled via precipitation of curcumin from organic solvents using controlled evaporation method. The GPs loaded with anti-inflammatory drugs can be used as potential treatment in inflammatory bowel diseases such Crohn’s disease and ulcerous colitis.

Czech name

—

Czech description

—

Type

O - Miscellaneous

CEP classification

—

OECD FORD branch

20401 - Chemical engineering (plants, products)

Project

<a href="/en/project/NV16-27522A" target="_blank" >NV16-27522A: Natural bioactive compounds encapsulated in glucan microparticles as biomaterials suitable in the treatment of inflammatory bowel diseases</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů