The Glucan Particles as Potential Carriers for Anti-inflammatory Substance Curcumin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43919871" target="_blank" >RIV/60461373:22340/19:43919871 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

The Glucan Particles as Potential Carriers for Anti-inflammatory Substance Curcumin

Original language description

Inflammatory bowel diseases (IBD), a group into which mainly Crohn’s disease and ulcerous colitis belong, are commonly spread through the world. A new option for treatment of IBD by using natural products is targeted in this project. Curcumin is phenolic compound with anti-inflammatory and antioxidant activity, therefore can be used as potential substance in the treatment of IBD. But it is poorly soluble in water and it has low bioavailability in organism. Hence, glucan particles (GPs) can be used as a vehicle, since β-glucan can interact with immunity system in organism. The GPs can be phagocytosed in the guts by lymphatic cells that are mostly presented in inflammation which is typical symptom for IBD. The porous GPs, containing curcumin as an active substance, can deliver their content into the targeted inflammatory area and increase its bioavailability. GPs with suitable properties were prepared from baker’s yeast Saccharomyces cerevisiae. The loaded microparticles were prepared by mixing a solution of curcumin with GPs and subsequently removing the solvent by controlled evaporation. The anti-inflammatory activity of prepared microparticles was confirmed in vitro on macrophage-like cells and in vivo in rats. GPs with incorporated curcumin are a promising delivery system, especially for diseases connected with the immune system, and can be used in treatment of IBD in the future.

Czech name

—

Czech description

—

Type

O - Miscellaneous

CEP classification

—

OECD FORD branch

20401 - Chemical engineering (plants, products)

Project

<a href="/en/project/NV16-27522A" target="_blank" >NV16-27522A: Natural bioactive compounds encapsulated in glucan microparticles as biomaterials suitable in the treatment of inflammatory bowel diseases</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů