Ex vivo vibration spectroscopic analysis of colorectal polyps for the early diagnosis of colorectal carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922104" target="_blank" >RIV/60461373:22340/21:43922104 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10435070 RIV/00064165:_____/21:10435070

Result on the web

<a href="https://www.mdpi.com/2075-4418/11/11/2048/htm" target="_blank" >https://www.mdpi.com/2075-4418/11/11/2048/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/diagnostics11112048" target="_blank" >10.3390/diagnostics11112048</a>

Result language

angličtina

Original language name

Ex vivo vibration spectroscopic analysis of colorectal polyps for the early diagnosis of colorectal carcinoma

Original language description

Colorectal cancer is one of the most common and often fatal cancers in humans, but it has the highest chance of a cure if detected at an early precancerous stage. Carcinogenesis in the colon begins as an uncontrolled growth forming polyps. Some of these polyps can finally be converted to colon cancer. Early diagnosis of adenomatous polyps is the main approach for screening and preventing colorectal cancer, and vibration spectroscopy can be used for this purpose. This work is focused on evaluating FTIR and Raman spectroscopy as a tool in the ex vivo analysis of colorectal polyps, which could be important for the early diagnosis of colorectal carcinoma. Multivariate analyses (PCA and LDA) were used to assist the spectroscopic discrimination of normal colon tissue, as well as benign and malignant colon polyps. The spectra demonstrated evident differences in the characteristic bands of the main tissue constituents, i.e., proteins, nucleic acids, lipids, polysaccharides, etc. Suitable models for discriminating the three mentioned diagnostic groups were proposed based on multivariate analyses of the spectroscopic data. LDA classification was especially successful in the case of a combined set of 55 variables from the FTIR, FT Raman and dispersion Raman spectra. This model can be proposed for ex vivo colorectal cancer diagnostics in combination with the colonoscopic extraction of colon polyps for further testing. This pilot study is a precursor for the further evaluation of the diagnostic potential for the simultaneous in vivo application of colonoscopic Raman probes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

<a href="/en/project/NU20-09-00229" target="_blank" >NU20-09-00229: The development of novel analytical approaches for early diagnosis of adenomatous polyps and prevention of colorectal carcinoma</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diagnostics

ISSN

2075-4418

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

20

Pages from-to

2048

UT code for WoS article

000726218300001

EID of the result in the Scopus database

2-s2.0-85118895910