Evaluation of IR and Raman spectroscopic markers of human collagens: Insides for indicating colorectal carcinogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F23%3A43925973" target="_blank" >RIV/60461373:22330/23:43925973 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10467679 RIV/60461373:22340/23:43925973 RIV/00064165:_____/23:10467679
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1386142523003499?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1386142523003499?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.saa.2023.122664" target="_blank" >10.1016/j.saa.2023.122664</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of IR and Raman spectroscopic markers of human collagens: Insides for indicating colorectal carcinogenesis
Original language description
Vibrational spectroscopic methods are widely used in the molecular diagnostics of carcinogenesis. Collagen, a component of connective tissue, plays a special role as a biochemical marker of pathological changes in tissues. The vibrational bands of collagens are very promising to distinguish between normal colon tissue, benign and malignant colon polyps. Differences in these bands indicate changes in the amount, structure, conformation and the ratio between the individual structural forms (subtypes) of this protein. The screening of specific collagen markers of colorectal carcinogenesis was carried out based on the FTIR and Raman (lambdaex 785nm) spectra of colon tissue samples and purified human collagens. It was found that individual types of human collagens showed significant differences in their vibrational spectra, and specific spectral markers were found for them. These collagen bands were assigned to specific vibrations in the polypeptide backbone, amino acid side chains and carbohydrate moieties. The corresponding spectral regions for colon tissues and colon polyps were investigated for the contribution of collagen vibrations. Mentioned spectral differences in collagen spectroscopic markers could be of interest for early ex vivo diagnosis of colorectal carcinoma if combine vibrational spectroscopy and colonoscopy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/NU20-09-00229" target="_blank" >NU20-09-00229: The development of novel analytical approaches for early diagnosis of adenomatous polyps and prevention of colorectal carcinoma</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
ISSN
1386-1425
e-ISSN
1873-3557
Volume of the periodical
296
Issue of the periodical within the volume
2023-Mar-24
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
15
Pages from-to
122664
UT code for WoS article
001055072900001
EID of the result in the Scopus database
2-s2.0-85151443463