Electrochemically deposited cobalt bis(dicarbollide) derivative and the detection of neuroblastoma markers on the electrode surface
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43923963" target="_blank" >RIV/60461373:22340/22:43923963 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S157266572200666X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S157266572200666X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jelechem.2022.116674" target="_blank" >10.1016/j.jelechem.2022.116674</a>
Alternative languages
Result language
angličtina
Original language name
Electrochemically deposited cobalt bis(dicarbollide) derivative and the detection of neuroblastoma markers on the electrode surface
Original language description
A cobalt bis(dicarbollide) derivative deposited onto the surface of a graphite electrode through an electrochemically oxidized o-phenylenediamine unit (pCB-oPD) is proposed for the detection of catecholamine metabolites, namely homovanillic acid (HVA) and vanillylmandelic acid (VMA). These metabolites are diagnostic markers of neuroblastoma. The set of electrochemical techniques, electrochemical impedance spectroscopy (EIS), potentiometry, and differential pulse voltammetry (DPV), makes it possible to evaluate the options of the individual and simultaneous detection of metabolites. The values of association constants that were found between the pCB-oPD attached to the electrode surface and the metabolites showed a high affinity to HVA (2.5 × 105) compared to VMA (4.3 × 104). The binding of the metabolites to the pCB-oPD-modified electrode allows the differentiation of VMA and HVA in the mixture, which can be of practical interest.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
ISSN
1572-6657
e-ISSN
1873-2569
Volume of the periodical
921
Issue of the periodical within the volume
15 September 2022
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
116674
UT code for WoS article
000861235700005
EID of the result in the Scopus database
2-s2.0-85135855737