Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43924208" target="_blank" >RIV/60461373:22340/22:43924208 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10445373 RIV/00216208:11120/22:43923720 RIV/00216208:11150/22:10445373 RIV/00216224:14110/22:00127917 RIV/00216208:11310/22:10445373
Result on the web
<a href="https://link.springer.com/article/10.1007/s00418-022-02140-x" target="_blank" >https://link.springer.com/article/10.1007/s00418-022-02140-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00418-022-02140-x" target="_blank" >10.1007/s00418-022-02140-x</a>

Result language
angličtina
Original language name
Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammation
Original language description
Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to several diseases. In patients with cancer, autoimmune diseases, severe respiratory infections [e.g. coronavirus disease 2019 (COVID-19)] and wound healing, IL-6 plays a critical role in modulating the systemic and local microenvironment. Elevated serum levels of IL-6 interfere with the systemic immune response and are associated with disease progression and prognosis. As already noted, monoclonal antibodies blocking either IL-6 or binding of IL-6 to receptors have been used/tested successfully in the treatment of rheumatoid arthritis, many cancer types, and COVID-19. Therefore, in the present review, we compare the impact of IL-6 and anti-IL-6 therapy to demonstrate common (pathological) features of the studied diseases such as formation of granulation tissue with the presence of myofibroblasts and deposition of new extracellular matrix. We also discuss abnormal activation of other wound-healing-related pathways that have been implicated in autoimmune disorders, cancer or COVID-19. © 2022, The Author(s).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/EF16_019%2F0000785" target="_blank" >EF16_019/0000785: Center for Tumor Ecology - Research of the cancer microenvironment supporting cancer growth and spread</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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