Autoimmunity, cancer and COVID‑19 abnormally activate wound healing pathways: critical role of infammation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F22%3A00001191" target="_blank" >RIV/61383082:_____/22:00001191 - isvavai.cz</a>
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/35867145/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/35867145/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00418-022-02140-x" target="_blank" >10.1007/s00418-022-02140-x</a>
Alternative languages
Result language
angličtina
Original language name
Autoimmunity, cancer and COVID‑19 abnormally activate wound healing pathways: critical role of infammation
Original language description
Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to several diseases. In patients with cancer, autoimmune diseases, severe respiratory infections [e.g. coronavirus disease 2019 (COVID-19)] and wound healing, IL-6 plays a critical role in modulating the systemic and local microenvironment. Elevated serum levels of IL-6 interfere with the systemic immune response and are associated with disease progression and prognosis. As already noted, monoclonal antibodies blocking either IL-6 or binding of IL-6 to receptors have been used/tested successfully in the treatment of rheumatoid arthritis, many cancer types, and COVID-19. Therefore, in the present review, we compare the impact of IL-6 and anti-IL-6 therapy to demonstrate common (pathological) features of the studied diseases such as formation of granulation tissue with the presence of myofibroblasts and deposition of new extracellular matrix. We also discuss abnormal activation of other wound-healing-related pathways that have been implicated in autoimmune disorders, cancer or COVID-19.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
HISTOCHEMISTRY AND CELL BIOLOGY
ISSN
0948-6143
e-ISSN
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Volume of the periodical
158
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
415-434
UT code for WoS article
000828939900001
EID of the result in the Scopus database
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