Multispecies biofilm in an artificial wound bed—A novel model for in vitro assessment of solid antimicrobial dressings
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60917431%3A_____%2F14%3A00TA2902" target="_blank" >RIV/60917431:_____/14:00TA2902 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0167701214001304?np=y" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0167701214001304?np=y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mimet.2014.05.008" target="_blank" >10.1016/j.mimet.2014.05.008</a>
Alternative languages
Result language
angličtina
Original language name
Multispecies biofilm in an artificial wound bed—A novel model for in vitro assessment of solid antimicrobial dressings
Original language description
Wound infections represent a major problem, particularly in patients with chronic wounds. Bacteria in the wound exist mainly in the formof biofilms and are thus resistant to most antibiotics and antimicrobials. A simple and cost-effective in vitro model of chronic wound biofilms applied for testing treatments and solid devices, especially wound dressings, is presented in this work. The method is based on the well-established Lubbock chronic wound biofilm transferred onto an artificial agar wound bed. The biofilm formed by four bacterial species (Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis and Pseudomonas aeruginosa) was stable for up to 48 h post-transplant. The applicability of the model was evaluated by testing two common iodine wound treatments. These observations indicate that this method enables assessing the effects of treatments on established resilient wound biofilms and is clinically highly relevant.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FO - Dermatology and venereology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/TA03011029" target="_blank" >TA03011029: New wound dressings with programmed release of active substances for biofilm inhibition.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.