Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F14%3A00424576" target="_blank" >RIV/61388955:_____/14:00424576 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jorganchem.2013.07.059" target="_blank" >http://dx.doi.org/10.1016/j.jorganchem.2013.07.059</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jorganchem.2013.07.059" target="_blank" >10.1016/j.jorganchem.2013.07.059</a>

Result language
angličtina
Original language name
Study of the anticancer properties of methyl- and phenyl-substituted carbon- and silicon-bridged ansa-titanocene complexes
Original language description
The previously known complexes [Ti{(Me2CMe2C)(?5-C5H4)2}Cl2] (1), [Ti{Me2C(?5-C5H4)2}Cl2] (2), [Ti{Me2Si(?5-C5H4)2}Cl2] (4), [Ti{MePhSi(?5-C5H4)2}Cl2] (5) and [Ti{MePhSi(?5-C5Me4)2}Cl2] (6) have been prepared following reported procedures. The novel complex [Ti{MePhC(?5-C5H4)2}Cl2] (3) has been prepared and characterized. The cytotoxic activity of 1-6 has been tested after 72 h on melanoma A375 and B16, prostate cancer DU145 and LNCaP and colon cancer HCT116, SW620 and CT26CL25 cell lines observing a high cytotoxic activity of complexes 1 and 6 compared to the reference compound ([Ti(?5-C5H5)2}Cl2]). 1 and 6 have also been tested against primary normal mouse keratinocytes and lung fibroblasts. While viability of both type of primary cells was significantly less affected by 1 in comparison to the reference compound [Ti(?5-C5H5)2Cl2], compound 6 was completely nontoxic for nonmalignant cells, indicating a potential selectivity of this compound towards cancer cell lines. In addition CFSE
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP207%2F12%2F2368" target="_blank" >GAP207/12/2368: Group 4 metallocenes: activation of ligands for synthetic and catalytic applications</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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