Organization of Lipids in the Tear Film: A Molecular- Level View
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F14%3A00427289" target="_blank" >RIV/61388955:_____/14:00427289 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/14:00486568
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0092461" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0092461</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0092461" target="_blank" >10.1371/journal.pone.0092461</a>
Alternative languages
Result language
angličtina
Original language name
Organization of Lipids in the Tear Film: A Molecular- Level View
Original language description
Biophysical properties of the tear film lipid layer are studied at the molecular level employing coarse grain molecular dynamics (MD) simulations with a realistic model of the human tear film. In this model, polar lipids are chosen to reflect the currentknowledge on the lipidome of the tear film whereas typical Meibomian-origin lipids are included in the thick nonpolar lipids subphase. Simulation conditions mimic those experienced by the real human tear film during blinks. Namely, thermodynamic equilibrium simulations at different lateral compressions are performed to model varying surface pressure, and the dynamics of the system during a blink is studied by non-equilibrium MD simulations. Polar lipids separate their nonpolar counterparts from water by forming a monomolecular layer whereas the non-polar molecules establish a thick outermost lipid layer. Under lateral compression, the polar layer undulates and a sorting of polar lipids occurs. Moreover, formation of three-dimensional a
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
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UT code for WoS article
000333352800111
EID of the result in the Scopus database
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