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Behavior of sphingomyelin and ceramide in a tear film lipid layer model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00477822" target="_blank" >RIV/61388955:_____/17:00477822 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388963:_____/17:00477753

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.aanat.2016.10.005" target="_blank" >http://dx.doi.org/10.1016/j.aanat.2016.10.005</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.aanat.2016.10.005" target="_blank" >10.1016/j.aanat.2016.10.005</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Behavior of sphingomyelin and ceramide in a tear film lipid layer model

  • Original language description

    Tear film lipid layer is a complex lipid mixture forming the outermost interface between eye and environment. Its key characteristics, such as surface tension and structural stability, are governed by the presence of polar lipids. The origin of these lipids and exact composition of the mixture are still elusive. We focus on two minor polar lipid components of the tear film lipid later: sphingomyelin and ceramide. By employing coarse grain molecular dynamics in silico simulations accompanied by Langmuir balance experiments we provide molecular-level insight into behavior of these two lipids in a tear film lipid layer model. Sphingomyelin headgroups are significantly exposed at the water-lipids boundary while ceramide molecules are incorporated between other lipids frequently interacting with nonpolar lipids. Even though these two lipids increase surface tension of the film, their molecular-level behavior suggests that they have a stabilizing effect on the tear film lipid layer. (C) 2016 Elsevier GmbH. All rights reserved.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

    <a href="/en/project/GA15-14292S" target="_blank" >GA15-14292S: Investigation of the tear film lipid layer at the molecular level – molecular dynamics simulations and experiments employing model lipid films</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Annals of Anatomy-Anatomischer Anzeiger

  • ISSN

    0940-9602

  • e-ISSN

  • Volume of the periodical

    210

  • Issue of the periodical within the volume

    MAR 2017

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    7

  • Pages from-to

    128-134

  • UT code for WoS article

    000395610600016

  • EID of the result in the Scopus database

    2-s2.0-85007012006