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Study of 2-Nitrofluorene Interaction with DNA at a Glassy Carbon Electrode

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F16%3A00459775" target="_blank" >RIV/61388955:_____/16:00459775 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/16:10337460

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Study of 2-Nitrofluorene Interaction with DNA at a Glassy Carbon Electrode

  • Original language description

    2-Nitrofluorene (2-NF) is a nitrated polycyclic aromatic hydrocarbon (NPAH) which occurs as the environmental pollutant. It is a potential carcinogen and mutagen. Interaction of deoxyribonucleic acid (DNA) with 2-NF was monitored using an electrochemical DNA biosensor prepared from a glassy carbon electrode (GCE) and low-molecular-weight DNA by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and square-wave voltammetry (SWV).nThere were no damaging interactions observed between DNA and 2-NF using EIS. However, CV shows intercalation of this substance into the DNA structure to form the complex 2-NF–DNA. Intercalation was also observed by SWV, confirming intercalation to reduce the number of electroactive sites and thus reducing the peak heights of adenosine and guanosine.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    CG - Electrochemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GBP206%2F12%2FG151" target="_blank" >GBP206/12/G151: Center of novel approaches to bioanalysis and molecular diagnostics</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    XXXVI. Moderní elektrochemické metody. Sborník přednášek

  • ISBN

    978-80-905221-4-5

  • ISSN

  • e-ISSN

  • Number of pages

    5

  • Pages from-to

    196-200

  • Publisher name

    Best servis

  • Place of publication

    Ústí nad Labem

  • Event location

    Jetřichovice

  • Event date

    May 23, 2016

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article