Electrochemical Activity of Wedelolactone and Probing its Interaction with DNA Using Voltammetry at a Carbon Electrode
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F15%3AA1601F4W" target="_blank" >RIV/61988987:17310/15:A1601F4W - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/15:00455890 RIV/00216224:14740/15:00085529
Result on the web
<a href="http://dx.doi.org/10.1002/elan.201500177" target="_blank" >http://dx.doi.org/10.1002/elan.201500177</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elan.201500177" target="_blank" >10.1002/elan.201500177</a>
Alternative languages
Result language
angličtina
Original language name
Electrochemical Activity of Wedelolactone and Probing its Interaction with DNA Using Voltammetry at a Carbon Electrode
Original language description
Wedelolactone (WLA) is a polyphenolic coumestan derivative found in extracts of plants used in traditional medicine. Due to its cytostatic activity, WLA is one of natural compounds tested as potential anticancer drugs. In this work we for the first timestudied electrochemical properties of WLA using cyclic (CV) and square-wave (SWV) voltammetry at the basal-plane pyrolytic graphite electrode. A reversible pair of peaks, corresponding to catechol/o-benzoquinone redox system, was observed using CV around0.275V vs. Ag|AgCl|3M KCl reference electrode. Measurements of SWV signal of WLA in the presence of single- or double-stranded DNA suggested a weak interaction without evident preference for double-stranded DNA. An indirect assay, employing electroactive DNA intercalator doxorubicin as competitor, confirmed absence of intercalative DNA binding of WLA.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ELECTROANAL
ISSN
1040-0397
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
4
Pages from-to
2268-2271
UT code for WoS article
000362902700002
EID of the result in the Scopus database
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