Electron Attachment to Microhydrated Deoxycytidine Monophosphate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F18%3A00492265" target="_blank" >RIV/61388955:_____/18:00492265 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21340/18:00349561

Result on the web

<a href="http://dx.doi.org/10.1021/acs.jpcb.8b03033" target="_blank" >http://dx.doi.org/10.1021/acs.jpcb.8b03033</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jpcb.8b03033" target="_blank" >10.1021/acs.jpcb.8b03033</a>

Result language

angličtina

Original language name

Electron Attachment to Microhydrated Deoxycytidine Monophosphate

Original language description

DNA constituents are effectively decomposed via dissociative electron attachment (DEA). However, the DEA contribution to radiation damage in living tissues is a subject of ongoing discussion. We address an essential question, how aqueous environment influences the DEA to DNA. In particular, we report experimental fragmentation patterns for DEA to microhydrated 2-deoxycytidine 5-monophosphate (dCMP). Isolated dCMP was previously set as a model to describe mechanisms of DNA-strand breaks induced by secondary electrons and decomposes primarily by dissociation of the C-O phosphoester bond. We show that hydrated molecules decompose via dissociation of the C-N glycosidic bond followed by dissociation of the P-O bond. This significant change of the proposed mechanism can be interpreted by a reactive role of water in the postattachment dynamics. Comparison of the fragmentation with previous macroscopic irradiation studies suggests that the actual contribution of DEA to DNA radiation damage in living tissue is rather small.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10403 - Physical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Physical Chemistry B

ISSN

1520-6106

e-ISSN

—

Volume of the periodical

122

Issue of the periodical within the volume

20

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

5212-5217

UT code for WoS article

000433403500009

EID of the result in the Scopus database

2-s2.0-85046632565