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Dose-Rate Effects in Breaking DNA Strands by Short Pulses of Extreme Ultraviolet Radiation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F18%3A00506556" target="_blank" >RIV/61388955:_____/18:00506556 - isvavai.cz</a>

  • Alternative codes found

    RIV/68378271:_____/18:00496971 RIV/61389021:_____/18:00503532 RIV/61389005:_____/18:00496971 RIV/68407700:21340/18:00324188

  • Result on the web

    <a href="http://hdl.handle.net/11104/0297789" target="_blank" >http://hdl.handle.net/11104/0297789</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1667/RR14825.1" target="_blank" >10.1667/RR14825.1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dose-Rate Effects in Breaking DNA Strands by Short Pulses of Extreme Ultraviolet Radiation

  • Original language description

    In this study, we examined dose-rate effects on strand break formation in plasmid DNA induced by pulsed extreme ultraviolet (XUV) radiation. Dose delivered to the target molecule was controlled by attenuating the incident photon flux using aluminum filters as well as by changing the DNA/buffer-salt ratio in the irradiated sample. Irradiated samples were examined using agarose gel electrophoresis. Yields of single-and double-strand breaks (SSBs and DSBs) were determined as a function of the incident photon fluence. In addition, electrophoresis also revealed DNA cross-linking. Damaged DNA was inspected by means of atomic force microscopy (AFM). Both SSB and DSB yields decreased with dose rate increase. Quantum yields of SSBs at the highest photon fluence were comparable to yields of DSBs found after synchrotron irradiation. The average SSB/DSB ratio decreased only slightly at elevated dose rates. In conclusion, complex and/or clustered damages other than cross-links do not appear to be induced under the radiation conditions applied in this study. (C) 2018 by Radiation Research Society.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Radiation Research

  • ISSN

    0033-7587

  • e-ISSN

  • Volume of the periodical

    189

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    466-476

  • UT code for WoS article

    000430572800003

  • EID of the result in the Scopus database

    2-s2.0-85045934898