Application of hollow fibre based microextraction for voltammetric determination of vanillylmandelic acid in human urine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F19%3A00500248" target="_blank" >RIV/61388955:_____/19:00500248 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10393967
Result on the web
<a href="http://hdl.handle.net/11104/0292349" target="_blank" >http://hdl.handle.net/11104/0292349</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jelechem.2018.12.060" target="_blank" >10.1016/j.jelechem.2018.12.060</a>

Result language
angličtina
Original language name
Application of hollow fibre based microextraction for voltammetric determination of vanillylmandelic acid in human urine
Original language description
A new hollow-fibre microextraction method has been developed for the determination of a clinical biomarker vanillylmandelic acid (VMA) in human urine. The extraction was used in combination with differential pulse voltammetry (DPV) on cathodically pre-treated boron doped diamond electrode (BDDE). Butyl benzoate was found to be the optimum solvent for creation of supported liquid membrane. Optimum donor and acceptor phases were 0.1 mol L−1 HCl and 0.1 mol L−1 NaOH, respectively, optimum extraction time was 30 min. Linear range was from 0.5 to 100 μmol L−1 (R = 0.9989), with good repeatability (RSD 7.9% for 50 μmol L−1 VMA aqueous sample (n = 7)). The limit of detection (LOD) was 0.5 μmol L−1. The method was successfully applied for the determination of VMA in real human urine sample, using a standard addition method, obtained RSD being 8.1% (n = 5). The method is sufficiently selective and sensitive for its intended use as a screening tool for elevated concentration of VMA.n
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Project
<a href="/en/project/GA17-03868S" target="_blank" >GA17-03868S: New Methods of Electrochemical Monitoring of Biologically Active Organic Compounds in Environmental, Biological and Food Matrices</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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