Synthesis and Characterization of Hybrid Dimeric Steroid Spiroketals

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F22%3A00549377" target="_blank" >RIV/61388955:_____/22:00549377 - isvavai.cz</a>
Result on the web
<a href="https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1647-7610" target="_blank" >https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1647-7610</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1055/a-1647-7610" target="_blank" >10.1055/a-1647-7610</a>

Result language
angličtina
Original language name
Synthesis and Characterization of Hybrid Dimeric Steroid Spiroketals
Original language description
The synthesis of six dimeric spiroketals bearing an estradiol half fused to the 5 alpha- or 5 beta-epimers of androstane, cholestane, and spirostane nuclei is described. The synthetic procedure comprises the Sonogashira- coupling of different steroid alkynes with 2-iodoestradiol 17-monoacetate, followed by Pd-catalyzed spiroketalization. The structural characterization of the obtained hybrid dimers was performed using a combination of 1D and 2D NMR techniques, and was assisted by DFT calculations. Single crystal X-ray diffraction of one of the obtained compounds confirmed the proposed structures.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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