Specifically Targeting Capture and Photoinactivation of Viruses through Phosphatidylcholine-Ganglioside Vesicles with Photosensitizer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F24%3A00597145" target="_blank" >RIV/61388955:_____/24:00597145 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10484404
Result on the web
<a href="https://hdl.handle.net/11104/0355435" target="_blank" >https://hdl.handle.net/11104/0355435</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jacsau.4c00453" target="_blank" >10.1021/jacsau.4c00453</a>
Alternative languages
Result language
angličtina
Original language name
Specifically Targeting Capture and Photoinactivation of Viruses through Phosphatidylcholine-Ganglioside Vesicles with Photosensitizer
Original language description
Herein, we performed a simple virus capture and photoinactivation procedure using visible light on phosphatidylcholine vesicles. l-alpha-Phosphatidylcholine vesicles were enriched by viral receptors, GT1b gangliosides, and the nonpolar photosensitizer 5,10,15,20-tetraphenylporphyrin. These vesicles absorb in the blue region of visible light with a high quantum yield of antiviral singlet oxygen, O-2 ((1)Delta(g)). Through the successful incorporation of gangliosides into the structure of vesicles and the encapsulation of photosensitizers in their photoactive and monomeric state, the photogeneration of O-2((1)Delta(g)) was achieved with high efficiency on demand. This process was triggered by light, and specifically targeting/inactivating viruses were captured on ganglioside receptors due to the short lifetime (3.3 mu s) and diffusion pathway (approximately 100 nm) of O-2((1)Delta(g)). Time-resolved and steady-state luminescence as well as absorption spectroscopy were used to monitor the photoactivity of the photosensitizer and the photogeneration of O-2((1)Delta(g)) on the surface of the vesicles. The capture of model mouse polyomavirus and its inactivation were achieved using immunofluorescence methods, and loss of infectivity toward mouse fibroblast 3T6 cells was detected.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JACS Au
ISSN
2691-3704
e-ISSN
2691-3704
Volume of the periodical
4
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
2826-2831
UT code for WoS article
001282968000001
EID of the result in the Scopus database
2-s2.0-85200599576