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An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F04%3A00100782" target="_blank" >RIV/61388963:_____/04:00100782 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    An efficient synthesis of cytostatic mono and bis-alkynylpyrimidine derivatives by the Sonogashira cross-coupling reactions of 2,4-diamino-6-iodopyrimidine and 2-amino-4,6-dichloropyrimidine

  • Original language description

    A series of 6-alkynyl-2,4-diaminopyrimidine derivatives bearing various substituents at alkynyl moiety was prepared by the Sonogashira cross-coupling reaction of 2,4-diamino-6-iodopyrimidine using Pd(pph3)2Cl2 as catalyst. The same reaction was applied to 2-amino-4,6-dichloropyrimidine. Some of the resulting alkynyl pyrimidines showed considerable cytostatic activity

  • Czech name

    Výhodná syntéza mono- a bis-alkynylpyrimidinů Sonogashirovou reakcí 2,4-diamino-6-jodpyrimidinu a 2-amino-4,6-dichlorpyrimidinu

  • Czech description

    Byla připravena série 6-alkynyl-2,4-diaminopyrimidinů Sonogashirovou reakcí 2,4-diamino-6-chlorpyrimidinu s Pd(pph3)2Cl2 jako katalysátorem. Některé z látek měly význačný cytostatický účinek

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/IBS4055109" target="_blank" >IBS4055109: Acyclic nucleoside phosponates with antineoplastic activity</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Tetrahedron

  • ISSN

    0040-4020

  • e-ISSN

  • Volume of the periodical

    60

  • Issue of the periodical within the volume

    23

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    5

  • Pages from-to

    4983-4987

  • UT code for WoS article

  • EID of the result in the Scopus database