Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F04%3A57043032" target="_blank" >RIV/61388963:_____/04:57043032 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/04:00100807
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Synthesis of [19-2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates.
Original language description
Deuterated analogs of pregnenolone and pregnenolone sulfate with three atoms of deuterium in position 19 were prepared. 3beta-hydroxy[19-2H3]androst-5-en-17-one was prepared in 14 steps from 19-hydroxy-17-oxoandrost-5-en-3beta-yl acetate in 8.9% yield, the analogous sequence in the pregnenolone series gave 3beta-hydroxy[19-2H3]pregn-5-en-20-one in 7.3% yield. The content of d3-derivative was about 93-95% according to the mass spectra analysis. Corresponding sulfates were prepared via pyridinium salts in53 and 57% yields, respectively.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GA203%2F02%2F1440" target="_blank" >GA203/02/1440: Syntheses of neurosteroid sulfates labeled with deuterium and their monitoring in human brain tumor cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
—
Volume of the periodical
69
Issue of the periodical within the volume
N/A
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
161-171
UT code for WoS article
—
EID of the result in the Scopus database
—