In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1-and -2-catalyzed prostaglandin E2 biosyntheses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F05%3A00022309" target="_blank" >RIV/61388963:_____/05:00022309 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41610/05:13528
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1-and -2-catalyzed prostaglandin E2 biosyntheses
Original language description
Dithymoquinone, thymohydroquinone, thymol and thymoquinone, the compounds derived from N. sativa seeds, were investigated for their in vitro anti-inflammatory activities using cyclooxygenase-1 (COX-1) and-2 (COX-2) assays. Thymol was the most active against COX-1 with IC50 value of 0.2 .mu.M, while thymohydroquinone and thymoquinone exhibited the strongest inhibitory effect on COX-2 with IC50 values of 0.1 and 0.3 .mu.M, respectively.
Czech name
Inhibiční efekt tymolu a chinonů ze semen Nigella sativa na biosyntézu prostaglandinu E2 katalyzovanou cyklooxgenázami -1 a -2 in vitro
Czech description
Protizánětlivý účinek dithymochinonu, thymohydrochinonu, thymolu a thymochinonu obsažených v semenech N. sativa byl testován prostřednictvím inhibice aktivity cyklooxygenázy-1 (COX-1) a -2 (COX-2) in vitro. Nejvyšší inhibiční aktivitu vůči COX-1 vykazoval thymol (IC50 = 0,2 .mu.M), zatímco COX-2 byla nejvýrazněji inhibována thymohydrochinonem (IC50 = 0,1 .mu.M) a thymochinonem (IC50 = 0,3 .mu.M).
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Planta medica
ISSN
0032-0943
e-ISSN
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Volume of the periodical
71
Issue of the periodical within the volume
-
Country of publishing house
DE - GERMANY
Number of pages
4
Pages from-to
739-742
UT code for WoS article
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EID of the result in the Scopus database
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