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Synthesis of some N4-substituted derivatives of 1-[2-(phosphonomethoxy)ethyl]cytosine and its diisopropyl esters as a model reaction for the synthesis of N4-substituted derivatives of Cidofovir

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F05%3A00029207" target="_blank" >RIV/61388963:_____/05:00029207 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis of some N4-substituted derivatives of 1-[2-(phosphonomethoxy)ethyl]cytosine and its diisopropyl esters as a model reaction for the synthesis of N4-substituted derivatives of Cidofovir

  • Original language description

    We have studied the reaction of 1-[2-(phosphonomethoxy)ethyl]cytosine and its diisopropyl ester with triethylammonium hydrogensulfite in 60% aqueous methanol. In the presence of some primary or secondary amine salts, this reaction affords transaminated derivatives accompanied by uracil compounds. However, with certain amines the reaction failed.

  • Czech name

    Syntéza N4-substituovaných derivátů 1-[2-(phosphonomethoxy)ethyl]cytosinu a jeho diisopropyl esteru jako modelová reakce pro syntézu N4-substituovaných derivátů Cidofoviru

  • Czech description

    Byla zkoumána reakce 1-[2-(phosphonomethoxy)ethyl]cytosinu a jeho diisopropyl esteru s triethylammonium hydrogensulfitem v 60% vodném methanolu. Reakce poskytovala s vybranými solemi primárních nebo sekundárních aminů transaminační produkty doprovázené uracilovými protějšky. S některými aminy tato reakce selhala.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/1M0508" target="_blank" >1M0508: New Antivirals and Antineoplastics</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Collection of Czechoslovak Chemical Communications

  • ISSN

    0010-0765

  • e-ISSN

  • Volume of the periodical

    70

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    13

  • Pages from-to

    2066-2074

  • UT code for WoS article

  • EID of the result in the Scopus database