Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F06%3A00030752" target="_blank" >RIV/61388963:_____/06:00030752 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Syntheses of 19-[O-(carboxymethyl)oxime] haptens of epipregnanolone and pregnanolone
Original language description
O-(Carboxymethyl)oximes 1 and 2 derived from two epimeric 5beta-pregnanolones (3beta- hydroxy-5beta-pregnan-20-one and 3alpha-hydroxy-5beta-pregnan-20-one) in position 19 were prepared. Two synthetic routes were employed, both using protection of the 20-keto group after reduction into the (20R)-alcohol in the form of acetate. Both haptens, i.e., (19E)-3beta- and -3alpha-hydroxy-20-oxo-5beta-pregnan-19-al 19-[O-(carboxymethyl)oxime], were designed for the development of immunoassays of the correspondingparent neuroactive steroids.
Czech name
Syntézy 19-[O-(karboxymethyl)oximových haptenů od epipregnanolonu a pregnanolonu
Czech description
Byly připraveny O-(karboxymethyl)oximy 1 a 2, odvozené od dvou epimerických 5beta-pregnanolonů v poloze 19. Byly vypracovány dva syntetické přístupy využívající chránění 20-keto skupiny po redukci na (20R)-alkohol ve formě acetátu. Oba hapteny, tj. (19E)-3beta- a -3alfa-hydroxy-20-oxo-5beta-pregnan-19-al 19-[O-karboxymethyl)ixim], byly navrženy pro vývoj imunostanovení matečných neuroaktivních steroidů.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—
Result continuities
Project
<a href="/en/project/GA203%2F04%2F0123" target="_blank" >GA203/04/0123: Haptens for immunoassays of neuroactive steroids of pregnanolone type</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
—
Volume of the periodical
71
Issue of the periodical within the volume
-
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
120-128
UT code for WoS article
—
EID of the result in the Scopus database
—