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A peptide conjugate of vitamin E succinate targets breast cancer cells with high erbB2 expression

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F07%3A00081236" target="_blank" >RIV/61388963:_____/07:00081236 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    A peptide conjugate of vitamin E succinate targets breast cancer cells with high erbB2 expression

  • Original language description

    Overexpression of erbB2 is associated with resistance to apoptosis. Treating erbB2-low or erbB2-high cells with alpha-tocopheryl succinate (a-TOS) induced similar levels of apoptosis. a-TOS-LTVSPWY conjugate induced greater levels of apoptosis in erbB2-high cells. The level of apoptosis was suppressed by erbB2 RNA interference as well as by inhibition of either endocytotic or lysosomal function. a-TOS-LTVSPWY reduced erbB2-high breast carcinomas in FVB/N c-neu transgenic mice.

  • Czech name

    Konjugát peptidu s vitamínem E specificky rozpoznává nádorové buňky prsu s vysokou expresí erbB2 receptoru

  • Czech description

    Zvýšená exprese erbB2 je spojována s rezistencí buněk vůči apoptóze. Alfa-tokoferyl sukcinát a-TOS) indukoval podobnou úroveň apoptózy u buněk s nízkou i vysokou expresí erbB2. a-TOS-LTVSPWY konjugát indukoval vyšší úroveň apoptózy u buněk s vysokou expresí erbB2. Apoptóza u těchto buněk byla potlačena interferencí erbB2 RNA a připadně inhibicí jejich endocytických nebo lysozomálních funkcí. a-TOS-LTVSPWY konjugát redukoval prsní nádory s vysokou expresí erbB2 u FVB/N c-neu transgenních myší.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/QF3115" target="_blank" >QF3115: Development of vectors, carriers and adjuvants for the constructoin of DNA vaccines</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cancer Research

  • ISSN

    0008-5472

  • e-ISSN

  • Volume of the periodical

    67

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    3337-3344

  • UT code for WoS article

  • EID of the result in the Scopus database