A peptide conjugate of vitamin E succinate targets breast cancer cells with high erbB2 expression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F07%3A00081236" target="_blank" >RIV/61388963:_____/07:00081236 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A peptide conjugate of vitamin E succinate targets breast cancer cells with high erbB2 expression
Original language description
Overexpression of erbB2 is associated with resistance to apoptosis. Treating erbB2-low or erbB2-high cells with alpha-tocopheryl succinate (a-TOS) induced similar levels of apoptosis. a-TOS-LTVSPWY conjugate induced greater levels of apoptosis in erbB2-high cells. The level of apoptosis was suppressed by erbB2 RNA interference as well as by inhibition of either endocytotic or lysosomal function. a-TOS-LTVSPWY reduced erbB2-high breast carcinomas in FVB/N c-neu transgenic mice.
Czech name
Konjugát peptidu s vitamínem E specificky rozpoznává nádorové buňky prsu s vysokou expresí erbB2 receptoru
Czech description
Zvýšená exprese erbB2 je spojována s rezistencí buněk vůči apoptóze. Alfa-tokoferyl sukcinát a-TOS) indukoval podobnou úroveň apoptózy u buněk s nízkou i vysokou expresí erbB2. a-TOS-LTVSPWY konjugát indukoval vyšší úroveň apoptózy u buněk s vysokou expresí erbB2. Apoptóza u těchto buněk byla potlačena interferencí erbB2 RNA a připadně inhibicí jejich endocytických nebo lysozomálních funkcí. a-TOS-LTVSPWY konjugát redukoval prsní nádory s vysokou expresí erbB2 u FVB/N c-neu transgenních myší.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/QF3115" target="_blank" >QF3115: Development of vectors, carriers and adjuvants for the constructoin of DNA vaccines</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Research
ISSN
0008-5472
e-ISSN
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Volume of the periodical
67
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
3337-3344
UT code for WoS article
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EID of the result in the Scopus database
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