Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F07%3A00088888" target="_blank" >RIV/61388963:_____/07:00088888 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Structure-activity relationship of CART (cocaine- and amphetamine-regulated transcript) peptide fragments
Original language description
CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides in the central nervous system and periphery.We report specific binding of 125I-CART(61-102) to the rat adrenal pheochromocytoma PC12 cell line, both intact cells and cell membranes. In this study, we present synthesis of several new peptide fragments corresponding to structural loops of CART(61?102).The results showed that a compact structure containing three disulfide bridges is necessary for preservation of full biologicalactivity of CART peptides.
Czech name
Vztah mezi strukturou a aktivitou peptidu CART a jeho fragmentů
Czech description
CART (cocaine- and amphetamine-regulated transcript) peptidy jsou neuropeptidy, které se vyskytují v CNS a v periferii. Ukazujeme zde vazbu na 125I-CART(61-102) na potkaní tumorové buňky dřeně nadledvin PC12 linii, na celých buňkách a na jejich membránách. Tato studie prezentuje syntézu nových fragmentů peptidu CART souvisejících se strukturními smyčkami CART(61?102). Výsledky dokazují, že struktura se třemi S-S můstky je důležité pro zachování plné biologické aktivity CART peptidů.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA303%2F05%2F0614" target="_blank" >GA303/05/0614: Central and peripheral pathways underlying feeding-related effects of cocaine and amphetamine regulated transcript (CART) peptides</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Peptides
ISSN
0196-9781
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1945-1953
UT code for WoS article
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EID of the result in the Scopus database
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