Iodination of CART(61-102) peptide: Preserved binding and anorexigenic activity in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00541244" target="_blank" >RIV/61388963:_____/21:00541244 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1002/jlcr.3871" target="_blank" >https://doi.org/10.1002/jlcr.3871</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jlcr.3871" target="_blank" >10.1002/jlcr.3871</a>

Result language

angličtina

Original language name

Iodination of CART(61-102) peptide: Preserved binding and anorexigenic activity in mice

Original language description

CART (cocaine- and amphetamine-regulated transcript) peptides are involved in food intake regulation, stress, and other physiological functions. Although CART peptides have been known for over 25 years, their receptor(s) have not yet been characterized. In this short review, we will summarize our previous studies, where we reported specific binding of 125 I-CART(61-102) to PC12 rat pheochromocytoma cells. Competitive binding experiments performed with mono- and di-iodinated peptides and their isoforms with oxidized Met67 resulted in nanomolar binding affinity. Moreover, in our previous study, CART(61-102), as well as di-iodinated CART(61-102), have shown a strong anorexigenic effect in fasted lean mice after intracerebroventricular administration. In conclusion, from our previous studies, iodination of CART(61-102) resulted in mono- and di-iodinated analogs with or without oxidized Met67 . All analogs revealed a high affinity to binding sites at PC12 cells and preserved biological activity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Labelled Compounds and Radiopharmaceuticals

ISSN

0362-4803

e-ISSN

1099-1344

Volume of the periodical

64

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

3

Pages from-to

61-63

UT code for WoS article

000557468000001

EID of the result in the Scopus database

2-s2.0-85089188227