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Synthesis of novel carbocyclic nucleosides and Pro-Tides derived from 4-oxatricyclo[4.2.1.03,7]nonane-9-methanol

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F07%3A00092433" target="_blank" >RIV/61388963:_____/07:00092433 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis of novel carbocyclic nucleosides and Pro-Tides derived from 4-oxatricyclo[4.2.1.03,7]nonane-9-methanol

  • Original language description

    Novel racemic carbocyclic nucleoside analogues of thymine, 6-chloropurine, adenine, 6-(dimethylamino)purine, 6-(cyclopropylamino)purine, and 2-amino-6-chloropurine derived from 4-oxatricyclo[4.2.1.03,7]nonane-9-methanol and their phenyl N-[(S)-1-(methoxycarbonyl)ethyl]phosphoramidates were prepared. The target compounds were tested for anti-HIV-1 and anti-HIV-2 activities in human T-lymphocyte (CEM) cells.

  • Czech name

    Syntéza nových karbocyklických nukleosidů a Pro-Tidů odvozených od (4-oxatricyklo[4.2.1.03,7]non-9-yl)methanol

  • Czech description

    Byla připravena nová karbocyklická nukleosidová analoga thyminu, 6-chlorpurinu, adeninu, 6-(dimethylamino)purinu, 6-(cyklopropylamino)purinu a 2-amino-6-chlorpurin odvozených od 4-oxatricyklo[4.2.1.03,7]nonan-9-methanolu a jejich fenyl N-[(S)-1-(methoxykarbonyl)ethyl]fosforamidaty. Cílové látky byly testovány na aktivitu proti HIV-1 a HIV-2 v lidských T-lymfocytech (CEM).

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CC - Organic chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Collection of Czechoslovak Chemical Communications

  • ISSN

    0010-0765

  • e-ISSN

  • Volume of the periodical

    72

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    19

  • Pages from-to

    1331-1349

  • UT code for WoS article

  • EID of the result in the Scopus database